Desmoid Tumor With Ossification in Chest Wall: Possible Involvement of BAMBI Promoter Hypermethylation in Metaplastic Bone Formation

Abstract

Because both BMP and classical Wnt/beta-catenin/LEF1 signaling cooperatively and mutually induce differentiation of mesenchymal cells into osteoblastic cells and promote bone formation, the epigenetic event leading to the enhanced responsiveness to BMP signaling may play a crucial role in the formation of metaplastic bone.