High-Dose Vitamin D Intervention in Infants—Effects on Vitamin D Status, Calcium Homeostasis, and Bone Strength

Abstract

Vitamin D3 supplementation with up to 40 μg/d from age 2 wk to 3 months was safe and caused no hypercalcemia or hypercalciuria. The 40-μg dose maintained S-25-OHD above 80 nmol/liter in all infants. More extensive and longer intervention studies are necessary to assess long-term effects.