Preparation of Enantioenriched Axially Chiral Anilides via [2+2+2] Cycloaddition of 1,6-Diynes with Trimethylsilylynamides

Abstract

The rhodium-catalyzed enantioselective [2+2+2] cycloaddition of 1,6-diynes with trimethylsilylynamides provides enantio­enriched axially chiral anilides in poor to good yields with good to excellent enantioselectivity. Trimethylsilylynamides can be readily prepared­ in two steps starting from commercially available bis(trimethylsilyl)acetylene.