Hepatocyte NAD(P)H Oxidases as an Endogenous Source of Reactive Oxygen Species During Hepatitis C Virus Infection

Abstract

HCV induced a persistent elevation of Nox1 and Nox4 and increased nuclear localization of Nox4 in hepatocytes in vitro and in the human liver. Hepatocyte Nox proteins are likely to act as a persistent, endogenous source of ROS during HCV-induced pathogenesis.