Reversibility of hyperglycaemia and islet abnormalities in the high fat-fed female ZDF rat model of type 2 diabetes

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

The Lancet · 1998 · 8.2K citations

Obesity, Metabolic Syndrome, Diabetes Management +10

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group.

PubMed · 1998 · 4.3K citations

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

Alexandra E. Butler, Juliette Janson, Susan Bonner‐Weir et al. · Diabetes · 2003 · 4K citations

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.

Alfred Pick, J. B. Clark, Christian Kubstrup et al. · Diabetes · 1998 · 549 citations

Chronic Inhibition of Dipeptidyl Peptidase-4 With a Sitagliptin Analog Preserves Pancreatic β-Cell Mass and Function in a Rodent Model of Type 2 Diabetes

James Mu, John Woods, Yun-Ping Zhou et al. · Diabetes · 2006 · 450 citations · Full text

Dipeptidyl Peptidase-4, Insulin Signaling, Gastrointestinal Peptide Hormone +17