Frequency and Distribution of Occult Micrometastases in Lymph Nodes of Patients With Non-Small-Cell Lung Carcinoma

Abstract

The high frequency of occult nodal metastases in non-small-cell lung cancer makes it clear that, without immunohistochemistry, disease is understaged in many patients. Therefore, it seems essential that immunohistochemical evaluation of the lymph nodes be undertaken in clinical trials.