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First Glycosylation of Decarestrictine B and D: A Route to Hybrid Antibiotics
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1998
Year
Bioorganic ChemistryGlycobiologyMolecular BiologyHybrid AntibioticsAntimicrobial ChemotherapyChemical BiologyPharmaceutical ChemistryDrug ResistanceMedicinal ChemistryFirst GlycosylationDecarestrictine BNew Hybrid AntibioticsGlycosylationBiochemistryBioconjugationDrug DevelopmentPharmacologyGlycosyl DonorsAntibioticsNatural SciencesBisglycoside 1MedicineCarbohydrate-protein InteractionDrug Discovery
A set of new hybrid antibiotics can be generated by coupling the naturally occurring ten-membered lactones decarestrictine B and D, which lower cholesterol levels, with deoxygenated glycosyl donors. As demonstrated for bisglycoside 1 these novel glycoconjugates can show DNA-binding properties.