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New steroidal alkaloids from the chinese herb drug, "Bei-mu".
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1988
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Medicinal ChemistryTraditional Chinese MedicineMedicineHerbal MedicineNew Steroidal AlkaloidsHerb-drug InteractionSecondary MetaboliteOrganic ChemistryFranch.the StructuresPhytochemicalChinese Herb DrugPharmacologyThird AlkaloidPhytochemistryDrug DiscoveryNatural Product Synthesis
Three new steroidal alkaloids were isolated from the bulbs of Fritillaria delavayi FRANCH.The structures of delafrinone (1), delafrine (2) and the third alkaloid were deduced to be (22R, 25S)-3β, 16β-dihydroxy-5α-cevanin-6-one, (22S, 25R)-5α-cevanine-3β, 6β, 16β-triol and (22R, 25S)-solanid-5-enine-3β, 5α, 6β-triol (3), respectively, on the basis of spectral data and chemical evidence.