A Plant-Derived Hydrolysable Tannin Inhibits CFTR Chloride Channel: A Potential Treatment of Diarrhea

The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000.

Margaret Kosek, Caryn Bern, Richard L. Guerrant · PubMed · 2003 · 1.6K citations

Public Health, Child Health, Infectious Diseases +17

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin–induced intestinal fluid secretion

Tonghui Ma, Jay R. Thiagarajah, Hong Yang et al. · Journal of Clinical Investigation · 2002 · 632 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin–induced intestinal fluid secretion

Tonghui Ma, Jay R. Thiagarajah, Hong Yang et al. · Journal of Clinical Investigation · 2002 · 532 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Mechanism and Cellular Applications of a Green Fluorescent Protein-based Halide Sensor

Sujatha Jayaraman, Peter M. Haggie, Rebekka M. Wachter et al. · Journal of Biological Chemistry · 2000 · 312 citations · Full text

Natural Sciences, Biochemistry, Molecular Biology +17

Discovery of Glycine Hydrazide Pore-occluding CFTR Inhibitors

Chatchai Muanprasat, N.D. Sonawane, Danieli B. Salinas et al. · The Journal of General Physiology · 2004 · 261 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13