Annals of Neurology · 2005 · 176 citations · 19 references
MedicineGeneticsNeurologyDementiaMedical GeneticsNeurodegenerationFrontotemporal DementiaGenetic DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurogenetic DisordersNeuropathology Of DementiaAutosomal Dominant DementiaHereditary Inclusion Body MyopathyInclusion Body LesionsMissense MutationsNeuronal Intranuclear InclusionsUbiquitin BindingUbiquitin SystemUbiquitin-binding Domains
Mutations in the valosin-containing protein (VCP) gene on chromosome 9p13-p12 recently have been shown to cause autosomal dominant inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia. Here, we report the central nervous system autopsy findings in a 55-year-old German patient with inclusion body myopathy and frontotemporal dementia who harbors a heterozygous R155C missense mutation residing in the N-terminal CDC48 domain of VCP, which is involved in ubiquitin binding. We demonstrate that mutant VCP causes a novel type of frontotemporal dementia characterized by neuronal nuclear inclusions containing ubiquitin and VCP.
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