Mutation underlying resistance of Plasmodium berghei to atovaquone in the quinone binding domain 2 (Qo2) of the cytochrome b gene

Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4'-chlorophenyl) cyclohexyl]-3- hydroxy-1,4-naphthoquinone (566C80)

Mitchell Fry, Mary Pudney · Biochemical Pharmacology · 1992 · 533 citations

Medicine, Medicinal Chemistry, Pharmacology +10

Atovaquone, a Broad Spectrum Antiparasitic Drug, Collapses Mitochondrial Membrane Potential in a Malarial Parasite

Indresh K. Srivastava, Hagai Rottenberg, Akhil B. Vaidya · Journal of Biological Chemistry · 1997 · 433 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Mutations in <i>Plasmodium falciparum</i> Cytochrome <i>b</i> That Are Associated with Atovaquone Resistance Are Located at a Putative Drug-Binding Site

Michael Korsinczky, Nanhua Chen, Barbara Kotecka et al. · Antimicrobial Agents and Chemotherapy · 2000 · 379 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +16

Resistance mutations reveal the atovaquone‐binding domain of cytochrome <i>b</i> in malaria parasites

Indresh K. Srivastava, Joanne M. Morrisey, Élisabeth Darrouzet et al. · Molecular Microbiology · 1999 · 312 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria

Quinton L. Fivelman, Geoffrey A. Butcher, I. S. Adagu et al. · Malaria Journal · 2002 · 222 citations · Full text

Life Sciences, Infectious Diseases, Pharmacotherapy +17