Journal of Natural Products · 2005 · 50 citations · 8 references
PharmacyMedicinal ChemistryPharmacologyCancer PharmacologyStructure-activity RelationshipsSynthetic Medicinal ChemistryMedicinal PlantsNatural Product Drug DiscoveryOncology PharmacologyAnticancer ActivityAnticancer Natural ProductsTumor Cell Proliferation
Several natural guaianolides and synthetic derivatives of repin (1) were tested and found to be active against tumor cell replication. Repin (1) and both mono- and di-halohydrin analogues (2, 7-9, 11, 12) showed significant antitumor potency. A more effective compound (17) was obtained by esterificating repin with the paclitaxel side chain.
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