LIPOLYSIS AND ADENOSINE 3′,5′-CYCLIC MONOPHOSPHATE IN ADIPOSE TISSUE OF THE NEW ZEALAND OBESE MOUSE

Abstract

SUMMARY Isolated fat cells from young New Zealand obese mice (NZO/Bl) showed an impaired rate of glycerol release in response to isoprenaline. Old animals showed an increased rate of glycerol release. The impaired lipolysis in young animals may be caused by failure of the adenosine 3′,5′-cyclic monophosphate level to rise normally when isolated fat cells are treated with isoprenaline. It is proposed that the impaired lipolysis in young NZO/Bl mice is important in the development of obesity.