Synthesis, 3D pharmacophore, QSAR and docking studies of novel quinazoline derivatives with nitric oxide release moiety as preferential COX-2 inhibitors

Abstract

Four novel series of quinazoline derivatives <bold>IIIa–c</bold>, <bold>VIa–c</bold> and their NO-hybrid molecules as nitrate esters <bold>Va–c</bold> and <bold>VIIIa–c</bold> have been synthesized and evaluated for their anti-inflammatory activity <italic>in vivo</italic> and <italic>in vitro.</italic>