Cerebellocerebral Diaschisis Is the Likely Mechanism of Postsurgical Posterior Fossa Syndrome in Pediatric Patients with Midline Cerebellar Tumors

Abstract

Our data suggest that the primary cause of PFS is the bilateral surgical damage to the pECP. This leads to a trans-synaptic cerebral cortical dysfunction (a form of bilateral crossed cerebellocerebral diaschisis), which manifests with DSC-detectable global, but dominantly frontal, cortical hypoperfusion in patients with patients with PFS compared with age- and sex-matched control subjects.