THE EFFECTS OF BREFELDIN A (BFA) ON CELL CYCLE PROGRESSION INVOLVING THE MODULATION OF THE RETINOBLASTOMA PROTEIN (pRB) IN PC-3 PROSTATE CANCER CELLS

Abstract

These results suggest that BFA may be a potent cell cycle modulator, which post-translationally regulates pRB phosphorylation possibly by down-regulating cdk2, cdk4, and cyclin D1 and/or by up-regulating a phosphatase(s) capable of dephosphorylating pRB. Thus, BFA-induced growth inhibition in PC-3 cells appears to be at least partially due to the modulation of a pRB-mediated growth pathway.