Ki-ras mutations and p53 protein expressions in intrahepatic cholangiocarcinomas: Relation to gross tumor morphology

DNA sequencing with chain-terminating inhibitors

Frederick Sanger, S. Nicklen, Alan Coulson · Proceedings of the National Academy of Sciences · 1977 · 69.3K citations · Full text

Life Sciences, Microbiology, Molecular Biology +10

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

S M Hsu, Laurence Raine, Herbert Fanger · Journal of Histochemistry & Cytochemistry · 1981 · 14.3K citations · Full text

Life Sciences, Immunology, Immunopathology +8

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

Suzanne J. Baker, Sanford D. Markowitz, Eric R. Fearon et al. · Science · 1990 · 1.8K citations

Medicine, Genetics, Oncology +17

Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.

Ulf Gyllensten · Proceedings of the National Academy of Sciences · 1988 · 1.6K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

Ih‐Chang Hsu, Robert A. Metcalf, Tai‐ping Sun et al. · Nature · 1991 · 1.5K citations

Medicine, Genetics, Oncology +16