Combined liquid chromatography time‐of‐flight mass spectrometry: An application of ²⁵²Cf fission fragment induced desorption mass spectrometry

Abstract

Abstract A 252 Cf fission fragment induced desorption mass spectrometer has been coupled on‐line to a high‐performance liquid chromatograph. The polar effluent (MeOHH 2 O) is introduced directly into a rough vacuum stage, where a thin sample of non‐volatile compounds is collected in a vacuum‐drying process (<1 cm 3 min −1 ). The interface which spans the difference in operating pressure between the collection site and the ion source consists basically of a sample changing disk. Twelve discrete samples are collected consecutively and analysed, typically one per minute. The system has been tested for the quantitative analysis of some antitumor drugs in serum using homologous compounds as internal standards.