In vivo x-ray luminescence tomographic imaging with single-view data

Abstract

X-ray luminescence computed tomography (XLCT) is a new molecular imaging modality. In this Letter, we first in vivo tomographically image the near-IR-emitting nanophosphor (Gd₂O₃:Eu³⁺) in nude mice (N=2). In practically, incorporating the compressive sensing technique, the XLCT reconstruction is performed only using single-view data. The experimental results indicate that the single-view reconstruction is feasible to image XLCT in vivo. The location error is less than 1.5 mm. Further, the imaging time can be greatly reduced compared with previous XLCT systems. Therefore, it is suited for imaging fast distribution of x-ray-excitable nanophosphors within a biological object.