Genetic variants in PCSK9 in the Japanese population: Rare genetic variants in PCSK9 might collectively contribute to plasma LDL cholesterol levels in the general population

Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge

William T. Friedewald, Robert I. Levy, Donald S. Fredrickson · Clinical Chemistry · 1972 · 32.5K citations

Life Sciences, Biochemistry, Clinical Biochemistry +14

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

Marianne Abifadel, Mathilde Varret, Jean‐Pierre Rabès et al. · Nature Genetics · 2003 · 3K citations

Life Sciences, Genetics, Molecular Genetics +10

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9

Jonathan C. Cohen, Alexander Pertsemlidis, Ingrid K. Kotowski et al. · Nature Genetics · 2005 · 1.4K citations

Life Sciences, Genetics, Molecular Genetics +13

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation

Nabil G. Seidah, Suzanne Benjannet, L. Alexandra Wickham et al. · Proceedings of the National Academy of Sciences · 2003 · 1.2K citations · Full text

Life Sciences, Biochemistry, Apoptosis +14

Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol

Jonathan C. Cohen, Robert S. Kiss, Alexander Pertsemlidis et al. · Science · 2004 · 1.1K citations

Life Sciences, Genetics, Molecular Genetics +15