Influence of P-glycoprotein on brain uptake of [18F]MPPF in rats

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Alfred H. Schinkel, Els Wagenaar, Carla A.A.M. Mol et al. · Journal of Clinical Investigation · 1996 · 1.3K citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Alfred H. Schinkel, Els Wagenaar, Liesbeth van Deemter et al. · Journal of Clinical Investigation · 1995 · 1.1K citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Tracer Kinetic Modeling of the 5-HT1AReceptor Ligand [carbonyl-11C]WAY-100635 for PET

Roger N. Gunn, Peter A. Sargent, Christopher J. Bench et al. · NeuroImage · 1998 · 280 citations

Pharmacy, Chemistry, Pharmacokinetics +10

NAN-190: an arylpiperazine analog that antagonizes the stimulus effects of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT)

Richard A. Glennon, Noreen Naiman, M. Edward Pierson et al. · European Journal of Pharmacology · 1988 · 183 citations

Medicine, Medicinal Chemistry, Pharmacology +9

Complete <i>in vivo</i> reversal of P‐glycoprotein pump function in the blood‐brain barrier visualized with positron emission tomography

N. Harry Hendrikse, A. H. Schinkel, Elisabeth G.E. de Vries et al. · British Journal of Pharmacology · 1998 · 181 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +16