Aromatase-deficient (ArKO) mice accumulate excess adipose tissue

Positional cloning of the mouse obese gene and its human homologue

Yiying Zhang, Ricardo Proenca, Margherita Maffei et al. · Nature · 1994 · 13.4K citations

Life Sciences, Genetics, Molecular Genetics +12

Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

I. Sadaf Farooqi, Susan A. Jebb, Gill Langmack et al. · New England Journal of Medicine · 1999 · 2K citations · Full text

Medicine, Endocrinology, Pediatrics +17

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

Daniel J. Peet, Stephen D. Turley, Wenzhen Ma et al. · Cell · 1998 · 1.4K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens.

A Morishima, Melvin M. Grumbach, E R Simpson et al. · The Journal of Clinical Endocrinology & Metabolism · 1995 · 1.3K citations

Medicine, Endocrinology, Genetics +17

Increased adipose tissue in male and female estrogen receptor-α knockout mice

Patricia A. Heine, Julia A. Taylor, Gary A. Iwamoto et al. · Proceedings of the National Academy of Sciences · 2000 · 1.3K citations · Full text

Life Sciences, Endocrinology, Physiology +8