Interaction of drugs with bile components. II. Effect of bile on the absorption of indomethacin and phenylbutazone in rats.

Abstract

The effect of endogenous bile on the intestinal absorption of indomethacin and phenylbutazone was investigated in control rats and in bile fistula rats. Oral administration of both drugs in suspension gave lower plasma concentrations in bile fistula rats than in control animals. On the other hand, studies in which solutions of the two drugs were administered intraduodenally to control and bile fistula rats indicated that bile had no effect on their plasma levels. These results suggest that bile plays an important role in the dissolution step in the absorption processes of indomethacin and phenylbutazone.