Concepedia

Molecular cloning of the canine telomerase reverse transcriptase gene and its expression in neoplastic and non-neoplastic cells

Mitsuhiro Yazawa, Masaru Okuda, Noriko Kanaya, Sung-Hyeok Hong, Tomoko Takahashi, Emi Ohashi, Takayuki Nakagawa, Ryohei Nishimura, Nobuo Sasaki, Kenichi Masuda,

American Journal of Veterinary Research · 2003 · 12 citations · 27 references

DOIFull text

Open access

Abstract

Expression of TERT mRNA was closely associated with telomerase activity in neoplastic cells as well as some non-neoplastic cells from dogs. In addition to telomerase activity, expression of TERT mRNA can be used as a marker of tumor cells.

References

27

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

Nam W. Kim, Mieczyslaw A. Piatyszek, Karen R. Prowse et al. · Science · 1994 · 7.1K citations

, , +17

Telomeres shorten during ageing of human fibroblasts

Calvin B. Harley, A. B. Futcher, Carol W. Greider · Nature · 1990 · 5.6K citations

, , +4

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

Andrea Bodnár, Michel Ouellette, Maria Frolkis et al. · Science · 1998 · 4.9K citations

A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.

Robert K. Moyzis, Judy M. Buckingham, L. Scott Cram et al. · Proceedings of the National Academy of Sciences · 1988 · 2.3K citations · Full text

, , +18

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

Toru Nakamura, Gregg B. Morin, Karen Chapman et al. · Science · 1997 · 2.3K citations · Full text

, , +13