Mode of action of Nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: Is oxidative stress involved?

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Tim R. Mosmann · Journal of Immunological Methods · 1983 · 55.6K citations

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Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.

S T Smiley, Martin Reers, C Mottola-Hartshorn et al. · Proceedings of the National Academy of Sciences · 1991 · 1.6K citations

Life Sciences, Biophysics, Cell Biology +11

Characterization of the Cellular Reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): Subcellular Localization, Substrate Dependence, and Involvement of Mitochondrial Electron Transport in MTT Reduction

Michael V. Berridge, An S. Tan · Archives of Biochemistry and Biophysics · 1993 · 1.4K citations

Life Sciences, Biochemistry, Cell Biology +15

Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2′,7′-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2′,7′-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123

S. L. Hempel, Garry R. Buettner, Yunxia O’Malley et al. · Free Radical Biology and Medicine · 1999 · 740 citations

Life Sciences, Biochemistry, Molecular Biology +6

Trypanothione: A Novel Bis(glutathionyl)spermidine Cofactor for Glutathione Reductase in Trypanosomatids

Alan H. Fairlamb, Peter Blackburn, Peter Ulrich et al. · Science · 1985 · 678 citations

Life Sciences, Biochemistry, Molecular Biology +15