Transforming growth factor β exerts opposite effects from interleukin‐1β on cultured rabbit articular chondrocytes through reduction of interleukin‐1 receptor expression

Abstract

OBJECTIVE: The aim of the study was to determine whether transforming growth factor beta (TGF beta) modulates the effects and the receptor expression of interleukin-1 (IL-1) in rabbit articular chondrocytes (RAC). METHODS: Collagen, glycosaminoglycan, and collagenase production, together with 125I-labeled IL-1 binding, were analyzed in RAC cultures. RESULTS: TGF beta reduced both IL-1 effects on matrix metabolism and IL-1 receptor expression. CONCLUSION: TGF beta acts as an antagonist of the effects of IL-1 through down-regulation of its receptor expression.