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ALTERATIONS OF ADRENAL CORTICAL AND OVARIAN ACTIVITY FOLLOWING HYPOTHALAMIC LESIONS BASED ON EOSINOPHILE RESPONSE, HORMONE ASSAY AND HISTOLOGICAL EXAMINATION
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1955
Year
GynecologyAdrenal GlandPituitary GlandNeuroendocrine MechanismHealth SciencesAnimal PhysiologyStress HormoneEndocrine MechanismHypothalamusDestructive LesionsNervous SystemEndocrinologyOvarian HormoneAnterior LobeNeuroanatomyPhysiologyAdrenal HealthNeuroendocrine DisorderNeuroscienceCentral Nervous SystemStressful SituationsMedicine
THE influence exerted by the hypothalamus on the anterior lobe of the pituitary gland has been the subject of several reviews in the last few years (Harris, 1948; Haymaker and Anderson, 1955). One of the problems of particular interest has been that of identifying hypothalamic cell aggregates or areas as centers influencing or controlling specific anterior pituitary functions. The purpose of this study was to determine whether any particular hypothalamic cell group or area was involved in the release of the adrenocorticotrophic hormone (ACTH) and the gonadotrophic hormones from the anterior lobe of the pituitary gland. Several investigators have reported that destructive lesions in the hypothalamus in experimental animals prevent the release of ACTH which normally occurs in response to stressful situations (De Groot and Harris, 1950, 1952; Hume and Wittenstein, 1950; Porter, 1953; McCann, 1953). The methods for estimating ACTH-adrenal cortical hormone release employed by these workers were based on: