Localized ewing's sarcoma—treatment and results

Abstract

The experience at M. D. Anderson Hospital in the management of 59 patients with apparently localized Ewing's sarcoma from 1948 to May, 1972 is presented. Necropsy examination was performed in 18 cases. Disease-free survival times are compared between 19 patients treated by the combination of high-dose irradiation and intensive chemotherapy, and 40 patients treated by radiation therapy alone (25) or in combination with relatively less intensive drug therapy (15). Results favor the former group: local recurrence in 1 case of 19 compared to 19 of 40; and median time to first metastasis of >15 months compared to 8 months.