New Scalable Asymmetric Aminomethylation Reaction for the Synthesis of β²‐Amino Acids

Abstract

Abstract β‐Amino acids are useful tools in the design of peptidomimetics, and the development of new methods for their syntheses, particularly the synthesis of β 2 ‐amino acids, remains an important challenge. Here we report a new scalable route based on the aminomethylation of silyl ketene N,O‐acetals by Mannich‐type iminium electrophiles. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)