Pediatric Hematology and Oncology · 2001 · 22 citations · 3 references
MedicineNeurologyPediatricsChemotherapyPediatric NeurologySepsisPediatric Clinical ImmunologyPediatric LeukemiasPediatric NeuroimmunologyPediatric Neurologic DisordersPediatric SepsisAcute Lymphoblastic Leukemia TreatmentDifferential Diagnosis CriteriaDifferential Symptom DiagnosisGuillain-barré Syndrome PathogenesisPediatric Central Nervous System InfectionRespiratory Infection Diagnosis
A 4-year-old boy with acute lymphoblastic leukemia receiving maintenance treatment developed quadriparesis, facial palsy, difficulty in swallowing, and hypertension following a respiratory infection and candida septicemia. Examination of the cerebrospinal fluid was normal initially but later showed albuminocytologic dissociation, the characteristic finding of Guillain-Barré syndrome. Complete recovery occurred after treatment with intravenous immunoglobulin. Differential diagnosis of Guillain-Barré syndrome from vincristine toxicity in patients with leukemia and possible association with the infections are discussed.
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The neuromyopathy of vincristine in man
Walter G. Bradley, L.P. Lassman, G. W. Pearce et al. · Journal of the Neurological Sciences · 1970 · 263 citations