Structure and Dynamics of ¹³C,¹⁵N‐Labeled Lipopolysaccharides in a Membrane Mimetic

Abstract

The natural look of endotoxin: A new approach has been developed to determine the chemical structure, dynamics, and conformation of lipopolysaccharide (endotoxin, see structure) by solution NMR spectroscopy. Using isotope labeling and solubilization by dihexanoylphosphatidylcholine as a mimetic of the bacterial membrane, a general approach makes complex endotoxin molecules amenable to analysis by heteronuclear NMR methods. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.