Novel Isocyanide-Based One-Pot Multicomponent Syntheses of Tetrahydrobenzo[<i>b</i>][1,4]oxazepine and Malonamide Derivatives

Abstract

In this work, a novel one-pot multicomponent reaction of 2-aminophenols, Meldrum's acid, and isocyanides leads to the synthesis of tetrahydrobenzo[b][1,4]oxazepine or malonamide derivatives using 1 or 2 equiv of 2-aminophenols, respectively, in good to excellent yields at ambient temperature.