The value of serum aspartate aminotransferase and gamma‐glutamyl transpetidase as biomarkers in hepatotoxicity

Abstract

AST can reliably replace ALT when calculating pattern of liver injury in DILI, while GGT can only substitute ALP when the R value scores as hepatocellular. The biochemical signature of causative drugs does influence the validity of the ratios with AST or GGT.