Proceedings of the National Academy of Sciences · 1962 · 382 citations · 1 references
MedicineEndocrinologyPharmacologyMetabolic RegulationMolecular PharmacologySignal TransductionDiabetes ManagementDiabetes PharmacotherapyInsulin ResistanceInsulin Signaling In MetabolismInsulin TherapyMuscle PhysiologyInsulin Resistance SyndromeInsulin Resistance TreatmentMuscle Insulin SignalingObesity-associated Insulin ResistanceSkeletal Muscle Glucose MetabolismSkeletal Muscle Glucose UptakeSkeletal Muscle Insulin Resistance
Currently, no pharmacological therapies treat skeletal muscle insulin resistance in pathological conditions such as type 2 diabetes, age-associated diseases, and cancer. Therefore, there is an unmet need to identify the molecular mechanisms ...The molecular events governing skeletal muscle glucose uptake have pharmacological potential for managing insulin resistance in conditions such as obesity, diabetes, and cancer. With no current pharmacological treatments to target skeletal muscle insulin ...
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