A Tetrazolato‐Bridged Dinuclear Platinum(II) Complex Exhibits Markedly High in vivo Antitumor Activity against Pancreatic Cancer

Abstract

Coordinated against cancer: We synthesized the structural isomers of two tetrazolato-bridged dinuclear PtII complexes: [{cis-Pt(NH3)2}2(μ-OH)(μ-tetrazolato-N1,N2)](ClO4)2 and [{cis-Pt(NH3)2}2(μ-OH)(μ-tetrazolato-N2,N3)](ClO4)2. The in vivo antitumor activity of the latter was evaluated on xenograft tumors of H460 NSCLC and PANC-1 pancreatic cancer. The complex shows high efficacy against pancreatic cancer and inhibits tumor growth by 99 % relative to untreated control. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.