Ultrasonic Controlled Morphology Transformation of Hollow Calcium Phosphate Nanospheres: A Smart and Biocompatible Drug Release System

Abstract

Hollow-structured calcium phosphate nanospheres can be transferred into pin-shaped crystallites under the ultrasonic treatments, the release of encapsulated compounds can be on/off triggered, and its kinetics is precisely regulated by the power density, duty cycle, and application time of ultrasound.