Direct <i>anti</i>‐Selective Catalytic Asymmetric Mannich‐Type Reactions of α‐Ketoanilides for the Synthesis of γ‐Amino Amides and Azetidine‐2‐amides

Abstract

Abstract Breaking with convention : A homodinuclear nickel complex derived from a biphenyldiamine‐based Schiff base catalyzed an anti ‐selective Mannich‐type reaction of α‐ketoanilides (see scheme) to afford unique building blocks for the synthesis of azetidine‐2‐amides and α‐hydroxy γ‐amino amides. This approach stands in contrast to conventional Mannich‐type reactions for the synthesis of β‐amino carbonyl compounds. o ‐Ns= o ‐nitrobenzenesulfonyl. magnified image