Publication | Closed Access
Synthesis of 3-Hydroxy-2-Methylene Carbonyl Compounds - Effect of Catalyst and Substrate on Reaction Rate
57
Citations
5
References
1988
Year
Reaction RateEngineeringAbstract 3-Hydroxyquinuclidine EnhancesOrganic Chemistry3-Hydroxy-2-methylene Carbonyl CompoundsChemistryHeterocycle ChemistryChemical DerivativeChemical EngineeringHomogeneous CatalysisStereoselective SynthesisCatalytic ApplicationCatalysisPharmacologyPoor CatalystEnantioselective SynthesisCatalytic SynthesisSynthetic ChemistryMethyl Acrylate
Abstract 3-Hydroxyquinuclidine enhances the rate of formation of the title compounds whereas the acetylated derivative is a poor catalyst. A comparative study shows that methyl vinyl ketone is more reactive than methyl acrylate in the Baylis-Hillman reaction.
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