Molecular Recognition of Zwitterions: Enhanced Binding and Selective Recognition of Miltefosine by a Squaramide‐Based Host

Abstract

The importance of a synergic combination between electrostatic and hydrogen-bonding interactions has been demonstrated. A self-complementary amidosquarate-squaramide host for miltefosine has been disclosed. In DMSO, this rather structurally simple host exhibits high affinity and enhanced selectivity for miltefosine owing to the goal-keeping effect of the amidosquarate unit. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.