Treatment of Locally Advanced Cancer of the Head and Neck With 5'-Iododeoxyuridine and Hyperfractionated Radiation Therapy: Measurement of Cell Labeling and Thymidine Replacement

Abstract

Previous regimens using halogenated pyrimidine radiosensitizers have generally used protracted drug delivery schedules. In this study, a high level of IdUrd labeling was measured after 5-7 days of drug infusion. The halogenated pyrimidines deserve further study with the use of repetitive short courses to reduce toxicity and possibly improve efficacy.