Asymmetric tandem Michael addition–ylide olefination reaction for the synthesis of optically active cyclohexa-1,3-diene derivatives

Abstract

The reaction of a crotonate-derived chiral phosphonium salt with alpha,beta-unsaturated carbonyl compounds in the presence of Cs(2)CO(3) affords optically active cyclohexa-1,3-diene derivatives with up to 90% ee in good yields.