Formal Highly Enantioselective Organocatalytic Addition of Fluoromethyl Anion to α,β‐Unsaturated Aldehydes

Abstract

Symmetric fluoromethylation made easy: A highly enantioselective fluoromethyl addition to α,β-unsaturated aldehydes is described (see scheme). The synthesis of chiral fluorinated blocks, including δ-fluoro-β-aminoalcohol derivatives is disclosed. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.