Fast Determination of Ciprofloxacin by Batch Injection Analysis with Amperometric Detection and Capillary Electrophoresis with Capacitively Coupled Contactless Conductivity Detection

Abstract

Abstract We report fast, precise, selective, and sensitive electroanalytical methods for the determination of ciprofloxacin in milk and pharmaceutical samples by batch‐injection analysis with amperometric detection (BIA‐AMP) and by capillary electrophoresis with capacitively‐coupled contactless conductivity detection (CE‐C 4 D). Both methods required simple sample preparation protocols before analysis (milk samples were just diluted and tablets powdered and dissolved in electrolyte/water). The analytical features of BIA‐AMP and CE‐C 4 D methods include, respectively, low relative standard deviation values for repetitive measurements (2.8 % and 1.7 %, n =10), low detection limits (0.3 and 5.0 µmol L −1 ), elevated analytical frequency (80 and 120 h −1 ) and satisfactory accuracy (based on comparative determinations by HPLC and recovery values for spiked samples).