Resveratrol Inhibits Pathologic Retinal Neovascularization in<i>Vldlr</i>^−/−<i>Mice</i>

Abstract

Oral administration of resveratrol is protective against retinal neovascular lesions in Vldlr(-/-) mice by inhibiting Vegf expression and angiogenic activation of retinal endothelial cells. These results suggest that resveratrol might be a safe and effective intervention for treating patients with MacTel.