Clozapine as a potential treatment for refractory impulsive, compulsive, and punding behaviors in Parkinson’s disease

Abstract

There have been emerging cases of medication refractory obsessions, impulsivity, compulsivity, and/or punding in Parkinson's disease. These cases have proven difficult to treat, even for the experienced clinician. We report several medication refractory cases with a positive response to treatment with clozapine.