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Plasma lipid peroxides and alpha-tocopherol in critically ill patients

DOI

131

Citations

0

References

1984

Year

Kiyoshi Takeda, Yasuhiro Shimada, Masaru Amano, Toshiko Sakai, Toshiki Okada, Ikuto Yoshiya
Critical Care Medicine

Abstract

Plasma lipid peroxide measured as thiobarbituric acid reactive substances (TBARS) and alpha-tocopherol levels in 24 critically ill patients were compared with those of control subjects. The mean plasma alpha-tocopherol level was significantly lower and the mean TBARS level was significantly higher in critically ill patients. Eight ICU patients developed disseminated intravascular coagulation (DIC); the mean TBARS level during DIC was significantly above the mean pre-DIC level. These results indicate that lipid peroxidation may contribute to the development of DIC in critically ill patients.