Journal of Tropical Pediatrics · 2009 · 43 citations · 12 references
MedicineInfectious DiseasesPediatricsPediatric EpidemiologyPediatric Infectious DiseasesPediatric NephrologyAntiretroviral TherapyChronic Kidney DiseaseHiv EpidemiologyRenal DiseaseRenal Function TestsCd4 Cell Count MonitoringHiv Infection In InfantsKidney DiseasesMale-to-female RatioPediatric Antiretroviral TherapyProtein-to-creatinine RatioUrine Protein Testing
Sub-Saharan Africa is the epicentre of the HIV pandemic but there are few reports of HIV-related kidney diseases in children in this region. This study aimed to determine the prevalence of proteinuria in HIV-infected children at the Lagos University Teaching Hospital. Proteinuria was determined using urine protein-creatinine ratio. CD4+ cell count was determined for all the HIV-infected children. The mean age of the HIV-infected children was 74.4 +/- 35.6 months with a male: female ratio of 3:2. Compared with 6% of the 50 controls 20.5% of the 88 HIV-infected children had proteinuria (p = 0.026). Of 20 children with advanced clinical stage 40% had proteinuria compared with 14.7% of 68 children with milder stage (p = 0.004). Similarly, proteinuria was commoner among those with severe immunosuppression (p = 0.014). HAART use was not associated with significant difference in proteinuria prevalence (p = 0.491). Proteinuria was frequent among HIV-infected children, especially among those with advanced disease.
12
Samir K. Gupta, Joseph A. Eustace, Jonathan Winston et al. · Clinical Infectious Diseases · 2005 · 585 citations · Full text