2,2‐Dimethyl‐α,α,α′,α′‐tetrakis(β‐naphthyl)‐1,3‐dioxolan‐4,5‐dimethanol (DINOL) for the Titanate‐Mediated Enantioselective Addition of Diethylzinc to Aldehydes

Abstract

Et2Zn can be also added selectively to aliphatic aldehydes in selectivities that are hardly ever achievable otherwise (in some cases greater than 99.5:0.5), if 1, a seven-membered ring containing titanium, is used as catalyst in the presence of stoichiometric quantities of Ti-(OCHMe2)4. A linear relationship exists between the enantiomeric purity of auxiliary and product.