The Effects of 4-Aminopyridine and Bay K 8644 on Verapamil-Induced Cardiovascular Toxicity in Anesthetized Rats

Abstract

4-Aminopyridine improved mean arterial pressure and heart rate in a dose-dependent fashion; however, the higher infusion rate (2 mg/kg/h) necessary to improve mean arterial pressure and heart rate resulted in convulsions and excessive secretions. The reversal effects of Bay K 8644 on mean arterial pressure were transient and did not affect heart rate.