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A Kinetic Study on Rh/Binap-Catalyzed 1,4-Addition of Phenylboronic Acid to Enones: Negative Nonlinear Effect Caused by Predominant Homochiral Dimer Contribution
137
Citations
7
References
2006
Year
Chemical EngineeringNovel OrganocatalystsEngineeringBiochemistryNatural SciencesNegative Nonlinear EffectHomochiral DimerOrganic ChemistryOrganometallic CatalysisCatalysisPhenylboronic AcidChemistryHomogeneous CatalysisMolecular CatalysisReaction CalorimetryAsymmetric CatalysisEnantioselective SynthesisKinetic Study
A kinetic study on the Rh/binap-catalyzed 1,4-addition of phenylboronic acid using reaction calorimetry revealed that the catalytically inactive dimeric hydroxorhodium complex [Rh(OH)((R)-binap)]2 (RR-4) is the resting state. A negative NLE in eeprod and an amplified reaction rate were predicted and observed in the present reaction system characterized by the preferential formation of homochiral dimer.
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